The Saccharomyces Genome Database SGD is a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae , which is commonly known as baker's or budding yeast. The SGD provides Internet access to the complete Saccharomyces cerevisiae genomic DNA sequence , its genes and their products, the phenotypes of its mutants, and the literature supporting these data. In the peer-reviewed literature report, experiment result on function and interaction of yeast genes are extracted by high-quality manual curation and integrated within a well-developed database. The data are combined with quality high-throughput results and post on Locus Summary pages which is a powerful query engine and rich genome browser. Based on the complexity of information collection, multiple bioinformatic tools are used to integrate information and allow productive discovery of new biological details. The SGD resource also provide a platform from which to investigate related genes and pathways in higher organisms.
Beginner’s guide to comparative bacterial genome analysis using next-generation sequence data
National Human Genome Research Institute Home | NHGRI
Context: While upper tract urothelial carcinoma UTUC share histological appearance with bladder cancer BC , the former has differences in etiology and clinical phenotype consistent with characteristic molecular alterations. Objective: To systematically evaluate current genomic sequencing and proteomic data examining molecular alterations in UTUC. Evidence synthesis: A total of 46 publications were selected for inclusion in this report, including 13 studies assessing genome-wide alterations, 18 studies assessing gene expression or microRNA expression profiles, three studies assessing proteomics, one study assessing genome-wide DNA methylation, and 14 studies evaluating distinct pathway alteration patterns. Our findings are limited by tumor and patient heterogeneity and different platforms used in the studies. Consequently, molecular subtypes differ according to location. Further work is needed to define the epigenomic and proteomic features of UTUC, and understand the mechanisms by which they shape the clinical behavior of UTUC.
Genome sequencing: a systematic review of health economic evidence
Genome sequencing refers to the process of determining the order of the nucleotides bases— adenine, guanine, cytosine, and thymine in a molecule of DNA or the genome of an organism. The methods of sequencing have become a game-changer in modern biological and medical fields. DNA sequencing has accelerated not only biological research and discovery but also enhanced medical diagnostics and treatment of diseases. Information on exact sequences of nucleotides in DNA has aided in various applied fields of biology such as molecular and forensic biology, virology, medicine, recombinant DNA technology, biological systematics, and bioinformatics.
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