Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of approved anticancer drugs, constituting the active domain, and a set of 2, natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules Neoechinulin, Colchicine, and Piperolactam have already been experimentally screened for their anticancer activity and found active.
Anticancer Research - Wikipedia
This work explored different modalities for the optimization of the properties of thermoresponsive nanogels, with regard to their application as drug carriers in anticancer therapy. The ability of nanogels to reversibly bind different chemotherapeutic drugs was investigated, following different strategies. The main focus was the implementation of synthetic procedures that allowed the incorporation of dendritic structures into nanogels, together with the design of multicompartimental nanogels as drug carriers with improved versatility. In order to successfully translate these synthetic efforts into nanogels showing good in vivo compatibility, thermoresponsive nanogels were investigated for their ability to interact with blood proteins in physiological conditions. The assessment of the protein corona around thermoresponsive nanogels, after their incubation in human serum and plasma, was described in Section 3. These studies focused on the understanding of polymer — protein associations in physiological conditions with regard to the role of the single constituents of thermoresponsive nanogels in the interaction with proteins, namely thermoresponsive polymers and dPG. In order to direct the drug carrier to the desired target in vivo and prevent its sequestration from the bloodstream, unwanted interactions with opsonins at a protein corona level should be avoided.
Anticancer activity of medicinal plants thesis proposal
Anticancer Research is an independent international peer-reviewed medical journal published by the International Institute of Anticancer Research , addressing experimental and clinical topics in oncology. Issues are released monthly print and online by Highwire Press , and an annual Index is also published. Anticancer Research was established in by John G. According to the Journal Citation Reports , the journal had a impact factor of 1.